Accidental Opioid Overdose

Accidental opioid overdose is more common than you think

Accidental drug overdose is the leading cause of accidental death in the US.; most of these involve opioids.

Even when opioids are taken as prescribed by a healthcare provider, accidents can happen. You could accidentally take more than recommended. Your medicines may interact in ways you didn’t expect. You may have a medical condition that puts you at more risk than you thought. Someone could get into your medicine cabinet.

How to recognize an opioid overdose emergency

During an opioid overdose breathing can decline drastically or stop, causing brain damage and death. Some signs of an opioid overdose include:

Person will not wake up and does not respond to your voice or touch

Breathing is very slow, irregular, or has stopped

Center part of their eye is very small, also known as “pinpoint pupils”

Take control of your safety. Talk to your doctor about your risk factors. Be ready with KLOXXADO®.

Take action right away

Take action if you suspect an opioid overdose emergency, even if you’re not sure. It could save someone’s life.

Administer Naloxone

Naloxone is a life-saving medication that counters the effects of an opioid overdose.

Call 911

Explain that someone is not responsive and not breathing.

Stay With the Person

Help them feel more comfortable until emergency help arrives.

Give More Naloxone (if needed)

If a person doesn’t respond or responds then relapses into overdose symptoms, give additional doses of KLOXXADO® every 2-3 minutes until help arrives.

A bystander was present for nearly 40% of fatal overdoses.

The Opioid Epidemic

With the spread of illegally-made, synthetic opioids like fentanyl, overdose deaths have grown across ages, races, ethnicities and communities.

Take Action

Facts About Fentanyl

Extremely potent, illegally-made synthetic opioids such as fentanyl and carfentanil are the most common drugs involved in overdose deaths in the United States.

Get the Facts

How To Recognize An Opioid Overdose Emergency

Here’s what to look for and what to do if you suspect an opioid overdose emergency.

Download

See More Resources ›

Important Safety Information and Indication for KLOXXADO® (naloxone HCl) NASAL SPRAY 8 mg

What is the most important information I should know about KLOXXADO® Nasal Spray?

Get emergency medical help right away after giving the first dose of KLOXXADO® Nasal Spray. The signs and symptoms of an opioid emergency can return after KLOXXADO® Nasal Spray is given. If this happens, give another dose after 2 to 3 minutes using a new KLOXXADO® Nasal Spray and watch the person closely until emergency help is received.

Important Safety Information and Indication for KLOXXADO® (naloxone HCl) NASAL SPRAY 8 mg

What is KLOXXADO® Nasal Spray?

KLOXXADO® Nasal Spray is a prescription medicine used for the treatment of an opioid emergency such as an overdose or a possible opioid overdose in adults and children with signs of breathing problems and severe sleepiness or not being able to respond.
KLOXXADO® Nasal Spray is to be given right away and does not take the place of emergency medical care.
Get emergency medical help right away after giving the first dose of KLOXXADO® Nasal Spray, even if the person wakes up.

What is the most important information I should know about KLOXXADO® Nasal Spray?

The medicine in KLOXXADO® Nasal Spray is safe to use in people who are not taking opioids. KLOXXADO® Nasal Spray is not intended for self-administration.

What should I tell my healthcare provider (pharmacist or prescriber) before using?

Before using KLOXXADO® Nasal Spray, tell your healthcare provider about all of your medical conditions, including if you:

have heart problems
are pregnant or plan to become pregnant. Use of KLOXXADO® Nasal Spray may cause withdrawal symptoms in your unborn baby. Your unborn baby should be examined by a healthcare provider right away after you use KLOXXADO® Nasal Spray.
are breastfeeding or plan to breastfeed. It is not known if KLOXXADO® Nasal Spray passes into your breast milk.

What are the possible serious side effects of KLOXXADO® Nasal Spray?

KLOXXADO® Nasal Spray may cause sudden opioid withdrawal symptoms including body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goose bumps, sweating, yawning, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramping, weakness, and increased blood pressure.

In infants under 4 weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include seizures, crying more than usual, and increased reflexes.

Who should not use KLOXXADO® Nasal Spray?

Do not use KLOXXADO® Nasal Spray if you are allergic to naloxone hydrochloride or any of the ingredients in KLOXXADO® Nasal Spray.

What are the most common side effects of KLOXXADO® nasal spray?

The most common side effects of KLOXXADO® Nasal Spray in adults include stomach-area (abdomen) pain, weakness, dizziness, headache, nose (nasal) discomfort, and a feeling like you are going to faint.

These are not all of the possible side effects of KLOXXADO® Nasal Spray. Please click here for the accompanying full Prescribing Information, including Patient Information, which includes a more complete discussion of the risks associated with KLOXXADO® Nasal Spray. Always contact your healthcare provider (pharmacist or prescriber) if you have questions or experience any side effects.

You are encouraged to report negative side effects to the FDA at: 1-800-FDA-1088 or www.fda.gov/medwatch. You can also contact Hikma Specialty USA Inc. at: us.hikma@primevigilance.com or call 1-877-845-0689 or 1-800-962-8364.

Accidental Overdose

What is an accidental opioid overdose?