Be ready to help save a life in an opioid emergency
With KLOXXADO® Nasal Spray, anyone can be prepared to reverse an opioid overdose. Once administered, it works in the brain, right at the opioid receptor, and has the ability to potentially reverse the deadly effects of the opioid causing the overdose.
Key steps for administering KLOXXADO® Nasal Spray
KLOXXADO® is not a substitute for emergency medical care.
1. REMOVE
Remove KLOXXADO® Nasal Spray from the box. Peel off the back tab with the triangle to open the KLOXXADO® Nasal Spray blister.
2. HOLD
Hold it with your thumb on the bottom and your first and middle fingers on either side of the nozzle.
3. INSERT
Insert the tip of the nozzle into one nostril until your fingers are against the bottom of the person’s nose.
4. PRESS
Press the plunger firmly to give the dose of KLOXXADO® Nasal Spray.
5. CALL 911
After giving KLOXXADO® Nasal Spray to someone, call 911 and stay with them until emergency help arrives.
6. ADDITIONAL DOSES
If a person is given KLOXXADO® and does not respond after 2-3 minutes, administer another dose.
If a person responds then overdose symptoms continue, additional doses of KLOXXADO® may be given every 2-3 minutes until emergency medical assistance arrives.
Administrate in accordance with the Quick Instructions.
Use as directed.
- If you’re experiencing an opioid overdose, you won’t be able to give KLOXXADO® Nasal Spray to yourself. Make sure those around you know about KLOXXADO® and where it’s stored, in case of an emergency.
- KLOXXADO® is ready to use and contains 8 mg of naloxone per spray in a single dose. Do not prime or test the device before use, and discard device after use.
How to store KLOXXADO® Nasal Spray
- Keep KLOXXADO® Nasal Spray in the blister and cartons provided until ready to use.
- Store at 68°F to 77°F (20°C to 25°C) with excursions permitted to 104°F (40°C) and to 41°F (5°C).
- Protect from light.
- Do not freeze. Do not expose to temperatures below 41°F (5°C) or above 104°F (40°C).
- Replace KLOXXADO® Nasal Spray before the expiration date on the box.
Keep KLOXXADO® Nasal Spray and all medicines out of the reach of children.
For more information, see complete prescribing information.
The Opioid Epidemic
With the spread of illegally-made, synthetic opioids like fentanyl, overdose deaths have grown across ages, races, ethnicities and communities.
Facts About Fentanyl
Extremely potent, illegally-made synthetic opioids such as fentanyl and carfentanil are the most common drugs involved in overdose deaths in the United States.
Understanding Overdose
More than a million Americans will die this decade of an opioid overdose. You could save someone.
KLOXXADO® Quick Use Instructions
Easy-to-follow instructions for administering KLOXXADO®.
Important Safety Information and Indication for KLOXXADO® (naloxone HCl) NASAL SPRAY 8 mg
What is the most important information I should know about KLOXXADO® Nasal Spray?
Get emergency medical help right away after giving the first dose of KLOXXADO® Nasal Spray. The signs and symptoms of an opioid emergency can return after KLOXXADO® Nasal Spray is given. If this happens, give another dose after 2 to 3 minutes using a new KLOXXADO® Nasal Spray and watch the person closely until emergency help is received.
Important Safety Information and Indication for KLOXXADO® (naloxone HCl) NASAL SPRAY 8 mg
What is KLOXXADO® Nasal Spray?
- KLOXXADO® Nasal Spray is a prescription medicine used for the treatment of an opioid emergency such as an overdose or a possible opioid overdose in adults and children with signs of breathing problems and severe sleepiness or not being able to respond.
- KLOXXADO® Nasal Spray is to be given right away and does not take the place of emergency medical care.
- Get emergency medical help right away after giving the first dose of KLOXXADO® Nasal Spray, even if the person wakes up.
What is the most important information I should know about KLOXXADO® Nasal Spray?
Get emergency medical help right away after giving the first dose of KLOXXADO® Nasal Spray. The signs and symptoms of an opioid emergency can return after KLOXXADO® Nasal Spray is given. If this happens, give another dose after 2 to 3 minutes using a new KLOXXADO® Nasal Spray and watch the person closely until emergency help is received.
The medicine in KLOXXADO® Nasal Spray is safe to use in people who are not taking opioids. KLOXXADO® Nasal Spray is not intended for self-administration.
What should I tell my healthcare provider (pharmacist or prescriber) before using?
Before using KLOXXADO® Nasal Spray, tell your healthcare provider about all of your medical conditions, including if you:
- have heart problems
- are pregnant or plan to become pregnant. Use of KLOXXADO® Nasal Spray may cause withdrawal symptoms in your unborn baby. Your unborn baby should be examined by a healthcare provider right away after you use KLOXXADO® Nasal Spray.
- are breastfeeding or plan to breastfeed. It is not known if KLOXXADO® Nasal Spray passes into your breast milk.
What are the possible serious side effects of KLOXXADO® Nasal Spray?
KLOXXADO® Nasal Spray may cause sudden opioid withdrawal symptoms including body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goose bumps, sweating, yawning, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramping, weakness, and increased blood pressure.
In infants under 4 weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include seizures, crying more than usual, and increased reflexes.
Who should not use KLOXXADO® Nasal Spray?
Do not use KLOXXADO® Nasal Spray if you are allergic to naloxone hydrochloride or any of the ingredients in KLOXXADO® Nasal Spray.
What are the most common side effects of KLOXXADO® nasal spray?
The most common side effects of KLOXXADO® Nasal Spray in adults include stomach-area (abdomen) pain, weakness, dizziness, headache, nose (nasal) discomfort, and a feeling like you are going to faint.
These are not all of the possible side effects of KLOXXADO® Nasal Spray. Please click here for the accompanying full Prescribing Information, including Patient Information, which includes a more complete discussion of the risks associated with KLOXXADO® Nasal Spray. Always contact your healthcare provider (pharmacist or prescriber) if you have questions or experience any side effects.
You are encouraged to report negative side effects to the FDA at: 1-800-FDA-1088 or www.fda.gov/medwatch. You can also contact Hikma Specialty USA Inc. at: us.hikma@primevigilance.com or call 1-877-845-0689 or 1-800-962-8364.
