How to use KloxxadoTM (naloxone HCl) nasal spray 8 mg

Be ready. Save a life from opioid overdose

With KloxxadoTM nasal spray, anyone can reverse an opioid overdose, possibly with just one dose.1

Once administered, it works in the brain, right at the opioid receptor, with front-line power to reverse the deadly effects of the opioid causing the overdose.1,2

How to administer KloxxadoTM nasal spray

When a life-threatening opioid overdose happens, administer KloxxadoTM – it’s just four simple steps. Then call 911. KloxxadoTM nasal spray is not a substitute for emergency medical care.1


  • If you’re experiencing an overdose, you can’t give KloxxadoTM nasal spray to yourself. Make sure those around you know about KloxxadoTM and where it’s stored, in case of an emergency.1
  • KloxxadoTM is ready to use. Do not prime or test the device.1
  • Stay with the person after giving KloxxadoTM to help them feel more comfortable until emergency help arrives.1
  • Overdoses involving highly potent opioids may require more naloxone to reverse.3
  • KloxxadoTM contains more naloxone per dose.1,4
  • Some opioids may outlast the reversal effect of KloxxadoTM, so the person may require additional dose(s).1

How to store KloxxadoTM nasal spray1

  • Keep KloxxadoTM nasal spray in the blister and cartons provided until ready to use.
  • Store at room temperature 60°F to 77°F (20°C to 25°C).
  • Protect from light.
  • Do not freeze. Do not expose to temperatures below 41°F (5°C) or above 104°F (40°C).
  • Replace KloxxadoTM nasal spray before the expiration date on the box.

Keep KloxxadoTM nasal spray and all medicines out of the reach of children.

For more information, see complete prescribing information.

Kloxxado™ Quick Use Instructions

How to identify an opioid overdose, administer KloxxadoTM nasal spray and stay safe until emergency help arrives.


How to get KloxxadoTM

Getting KloxxadoTM is simple with a prescription from your doctor. You can also save with the KloxxadoTM Savings Card.

See How


  1. KLOXXADO™ (naloxone HCl) Nasal Spray [prescribing information]. Columbus, OH: Hikma Specialty USA Inc., 2021
  2. FDA 2019, “Having Naloxone on Hand Can Save a Life During an Opioid Overdose,”, Accessed May 3, 2021.
  3. CDC 2021, “Fentanyl,”, Accessed May 3, 2021.
  4. NARCAN® (naloxone HCl) Nasal Spray [prescribing information]. Plymouth Meeting, PA: Emergent BioSolutions Inc., 2020.