If a patient misusing opioids obtains opioids from anywhere other than a pharmacy, they are at risk of acquiring counterfeit medications that contain illicitly manufactured synthetic opioids.10 In these situations, your patient may not be able to tell the difference between a true prescription opioid and a counterfeit medication.11

Overdoses on illicitly manufactured synthetic opioids may require more naloxone to reverse the overdose.10 It is important that your patient understand opioid safety, including having enough naloxone and knowing how to administer it.