Your pharmacy patients may be at increased risk for opioid overdose. Help them be ready with Kloxxado® (naloxone HCl) nasal spray 8 mg.

When it’s life or death, accept no substitutes

Kloxxado® delivers the highest dose of intranasal naloxone on the market.1

When 78% of opioid overdoses involve at least 8 mg of naloxone, anything less may not be enough to save a life.2 Kloxxado® is the only nasal spray that contains a full 8 mg of naloxone in a single dose.1

  • 2x more naloxone per device as Narcan®1,3
  • Savings card available
  • Stocked at all major wholesalers
  • No substitutes for Kloxxado®

Is your pharmacy prepared to dispense Kloxxado®? It’s simple and easy to keep in stock.

Overdose doesn’t wait for your wholesaler

Extremely potent, illegally-made synthetic opioids like fentanyl are the most common drugs involved in overdose deaths in the United States.4

If your patient has a prescription for Kloxxado®, their doctor may see a need for a higher dose of naloxone – for instance, if they’re at an increased risk of a fentanyl overdose – and your patient may not want to talk about it.

Trust the prescription; don’t offer a half-dose generic or half-dose OTC.

Keep Kloxxado® in stock. A fentanyl overdose won’t wait for your warehouse or wholesaler. You shouldn’t either.

More than 150 people die from synthetic opioid overdose each day4

What do the experts say about naloxone?

Opioid overdoses hit fast and may need more naloxone

How do I stock and dispense Kloxxado®?

Kloxxado® is available from your regular wholesalers. Here’s the item number to find it. Need help? Contact us.

Product Image Strength Unit Size/Quantity NDC Number WAC Wholesaler Item #
8mg / 0.1mL Carton: 2-unit dose nasal spray devices 59467-679-01 $125.00 AmeriSource Bergen 10260066
Cardinal 5735550
McKesson 2342855
Morris & Dickson 104455

Product Description: Clear, colorless-to-yellow solution supplied in a single-dose spray device that consists of a stoppered glass vial encased in a container holder fitted with a spray actuator, cannula, and spray pin.

Kloxxado® Quick Use Instructions

Easy-to-follow instructions for administering Kloxxado®.


  1. KLOXXADO® (naloxone HCl) Nasal Spray [prescribing information]. Columbus, OH: Hikma Specialty USA Inc., 2021.
  2. Abdelal R, Banerjee A, Carlberg-Racich S, Darwaza N, Ito D, Shoaff J, Epstein J. Real-World Study of Multiple Naloxone Administration for Opioid Overdose Reversal Among Bystanders. JMCP. 2021;27(10-a):S54.
  3. NARCAN® (naloxone HCl) Nasal Spray [prescribing information]. Plymouth Meeting, PA: Emergent BioSolutions, 2020.
  4. Fentanyl Facts. Centers for Disease Control and Prevention website. Available at: Accessed June 27, 2023.
  5. APhA Motion. American Pharmacists Association website. Available at: Accessed June 27, 2023.
  6. FDA Requiring Labeling Changes for Opioid Pain Medicines, Opioid Use Disorder Medicines Regarding Naloxone. US Food and Drug Administration website. Available at: Accessed June 27, 2023.
  7. AMA statement on FDA decision to make naloxone nasal. American Medical Association website. Available at: Accessed June 27, 2023.
  8. Non-Fatal Opioid Overdose and Associated Health Outcomes: Final Summary Report. ASPE website. Available at: Accessed June 25, 2023.
  9. Mell, Howard K et al., 2017. “Emergency Medical Services Response Times in Rural, Suburban, and Urban Areas.” JAMA Surgery, 152(10), 983–984.

* Maximum value of $40 per box, up to 2 boxes per redemption, up to 4 boxes per month. No activation is necessary. See eligibility and restrictions.

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Important Safety Information About KLOXXADO® (naloxone HCl) Nasal Spray 8 mg