Pharmacists2024-03-22T12:02:41-04:00

Pharmacists

Your pharmacy patients may be at increased risk for opioid overdose. Help them be ready with Kloxxado® (naloxone HCl) nasal spray 8 mg.

When it’s life or death, accept no substitutes

Kloxxado® delivers the highest dose of intranasal naloxone on the market.1

When 78% of opioid overdoses involve at least 8 mg of naloxone, anything less may not be enough to save a life.2 Kloxxado® is the only nasal spray that contains a full 8 mg of naloxone in a single dose.1

  • 2x more naloxone per device as Narcan®1,3
  • Savings card available
  • Stocked at all major wholesalers
  • No substitutes for Kloxxado®

Is your pharmacy prepared to dispense Kloxxado®? It’s simple and easy to keep in stock.

Overdose doesn’t wait for your wholesaler

Extremely potent, illegally-made synthetic opioids like fentanyl are the most common drugs involved in overdose deaths in the United States.4

If your patient has a prescription for Kloxxado®, their doctor may see a need for a higher dose of naloxone – for instance, if they’re at an increased risk of a fentanyl overdose – and your patient may not want to talk about it.

Trust the prescription; don’t offer a half-dose generic or half-dose OTC.

Keep Kloxxado® in stock. A fentanyl overdose won’t wait for your warehouse or wholesaler. You shouldn’t either.

Get the facts about fentanyl ›

More than 150 people die from synthetic opioid overdose each day4

What do the experts say about naloxone?

APhA Motion

APhA supports policies and practices that increase the availability of naloxone.5
Read more

FDA Recommendations

The FDA urges healthcare professionals to discuss naloxone with their patients.6
Read more

AMA Statement

“Now, we must make sure that the new version of naloxone is placed on the lowest cost-sharing tier with low or no cost-sharing and also available in pharmacies.”7
Read more

Opioid overdoses hit fast and may need more naloxone

People Use More Naloxone

78% of opioid overdoses involve at least 8 mg of naloxone.2 Kloxxado® is the only nasal spray that contains a full 8 mg in a single dose.1
See the difference

Minutes Matter

Just four minutes without breathing during an opioid overdose can cause permanent brain damage, but EMS takes 7 minutes on average to arrive on scene.8,9 Kloxxado® ensures you deliver a full 8mg in the first dose, leaving you another dose to spare just in case.1

Find out more

An Affordable Choice

Don’t let cost get in the way of saving a life. With the Kloxxado® Savings Card, eligible patients may pay as little as $0* for Kloxxado® naloxone nasal spray.

Find out more

How do I stock and dispense Kloxxado®?

Kloxxado® is available from your regular wholesalers. Here’s the item number to find it. Need help? Contact us.

Product Image Strength Unit Size/Quantity NDC Number WAC Wholesaler Item #
8mg / 0.1mL Carton: 2-unit dose nasal spray devices 59467-679-01 $125.00 AmeriSource Bergen 10260066
Cardinal 5735550
McKesson 2342855
Morris & Dickson 104455

Product Description: Clear, colorless-to-yellow solution supplied in a single-dose spray device that consists of a stoppered glass vial encased in a container holder fitted with a spray actuator, cannula, and spray pin.

Healthcare Resources

Access helpful online tools, videos, research studies, educational materials and more.

Get more resources

Healthcare FAQs

Find answers to questions about Kloxxado® for healthcare professionals.

See frequently asked questions

Attention Pharmacists

Kloxxado®️️ delivers the highest dose of intranasal naloxone on the market.2

Why 8 mg of naloxone?

Kloxxado® Quick Use Instructions

Easy-to-follow instructions for administering Kloxxado®.

See More Resources ›

References

  1. KLOXXADO® (naloxone HCl) Nasal Spray [prescribing information]. Columbus, OH: Hikma Specialty USA Inc., 2021.
  2. Abdelal R, Banerjee A, Carlberg-Racich S, Darwaza N, Ito D, Shoaff J, Epstein J. Real-World Study of Multiple Naloxone Administration for Opioid Overdose Reversal Among Bystanders. JMCP. 2021;27(10-a):S54.
  3. NARCAN® (naloxone HCl) Nasal Spray [prescribing information]. Plymouth Meeting, PA: Emergent BioSolutions, 2020.
  4. Fentanyl Facts. Centers for Disease Control and Prevention website. Available at: https://www.cdc.gov/stopoverdose/fentanyl/index.html. Accessed June 27, 2023.
  5. APhA Motion. American Pharmacists Association website. Available at: https://aphanet.pharmacist.com/sites/default/files/audience/NBI%20%234%20-%20Increasing%20Access%20to%20and%20Affodability%20of%20Naloxone%20-%20FINAL.pdf. Accessed June 27, 2023.
  6. FDA Requiring Labeling Changes for Opioid Pain Medicines, Opioid Use Disorder Medicines Regarding Naloxone. US Food and Drug Administration website. Available at: https://www.fda.gov/news-events/press-announcements/fda-requiring-labeling-changes-opioid-pain-medicines-opioid-use-disorder-medicines-regarding. Accessed June 27, 2023.
  7. AMA statement on FDA decision to make naloxone nasal. American Medical Association website. Available at: https://www.ama-assn.org/press-center/press-releases/ama-statement-fda-decision-naloxone-nasal. Accessed June 27, 2023.
  8. Non-Fatal Opioid Overdose and Associated Health Outcomes: Final Summary Report. ASPE website. Available at: https://aspe.hhs.gov/sites/default/files/migrated_legacy_files//190846/Nonfatal.pdf. Accessed June 25, 2023.
  9. Mell, Howard K et al., 2017. “Emergency Medical Services Response Times in Rural, Suburban, and Urban Areas.” JAMA Surgery, 152(10), 983–984. https://doi.org/10.1001/jamasurg.2017.2230.

* Maximum value of $40 per box, up to 2 boxes per redemption, up to 4 boxes per month. No activation is necessary. See eligibility and restrictions.

Important Safety Information About KLOXXADO® (naloxone HCl) Nasal Spray 8 mg

Contraindications

Hypersensitivity to naloxone hydrochloride or to any of the other ingredients

Warnings and Precautions

  • Use KLOXXADO® right away if you suspect an opioid overdose emergency, even if you are not sure, because an opioid overdose emergency can cause severe injury or death. Signs and symptoms of an opioid overdose emergency may include:
    • Unusual sleepiness; you are not able to awaken the person with a loud voice or by rubbing firmly on the middle of their chest (sternum).
    • Breathing problems, including slow or shallow breathing in someone difficult to awaken or who looks like they are not breathing.
    • The black circle in the center of the colored part of the eye (pupil) is very small (sometimes called “pinpoint pupils”) in someone difficult to awaken.
  • Family members, caregivers or other people who may have to use KLOXXADO® in an opioid overdose emergency should know where KLOXXADO® is stored and how to give KLOXXADO® before an opioid overdose emergency happens.
  • Get emergency medical help right away after using the first dose of KLOXXADO®. Rescue breathing or CPR (cardiopulmonary resuscitation) may be needed while waiting for emergency medical help.
  • The signs and symptoms of an opioid overdose emergency can return after KLOXXADO® is given. If this happens, give another dose after 2 to 3 minutes, using a new KLOXXADO® device, alternating nostrils, and watch the person closely until emergency medical help arrives.
  • Do not use KLOXXADO® if you are allergic to naloxone hydrochloride or any of the ingredients in KLOXXADO®.
  • KLOXXADO® can cause sudden and severe opioid withdrawal, the symptoms of which may include body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goosebumps, sweating, yawning, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramps, weakness and increased blood pressure.
  • In infants under 4 weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.
  • Tell your doctor about all of your medical conditions before using KLOXXADO®, including if you have heart problems, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed.
  • Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, drugs, vitamins and herbal supplements.

Side Effects

The following serious side effect is discussed in the full Prescribing Information for KLOXXADO®:

  • Sudden and Severe Opioid Withdrawal

Symptoms of sudden and severe opioid withdrawal resulting from the use of KLOXXADO® in someone regularly using opioids include: body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goosebumps, sweating, yawning, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramps, weakness and increased blood pressure.

Infants may have seizures, cry more than normal and have increased reflexes.

Some people may become aggressive after abrupt reversal of opioid overdose.

In two clinical studies, a total of 47 healthy adult volunteers were exposed to a single dose of KLOXXADO®, one spray in one nostril. Side effects were reported in two subjects for each of the following: abdominal pain, asthenia, dizziness, headache, nasal discomfort, and presyncope.

These are not all of the possible side effects of KLOXXADO®. Contact your doctor for medical advice about side effects.

Pregnancy, Infancy and Breastfeeding, Children

Tell your doctor if you are pregnant or plan to become pregnant. If you are pregnant and opioid dependent, use of KLOXXADO® may cause withdrawal symptoms in you and your unborn baby. A healthcare provider should monitor you and your unborn baby right away after you use KLOXXADO®.

There is no information regarding the presence of naloxone in human milk, the effects of naloxone on the breastfed infant or on milk production.

If the primary concern is an infant at risk of an overdose, consider whether other naloxone-containing products may be more appropriate.

KLOXXADO® nasal spray is safe and effective in children for known or suspected opioid overdose.

Dosage and Administration

Do not attempt to prime or test-fire the device. Each KLOXXADO® Nasal Spray contains only 1 dose of medicine and cannot be reused. Read the “instructions for use” at the end of the Prescribing Information and Medication Guide for detailed information about the right way to use KLOXXADO® Nasal Spray.

Storage and Handling

Store KLOXXADO® at room temperature between 68°F to 77°F (20°C to 25°C). Do not expose to temperatures below 41°F (5°C) or above 104°F (40°C). Do not freeze KLOXXADO®. Keep KLOXXADO® in its box until ready to use. Protect from light. Replace KLOXXADO® before the expiration date on the box. Keep KLOXXADO® and all medicines out of the reach of children.

For more information, please see the full Prescribing Information and Medication Guide.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch or call 1-800-FDA-1088.

Distributed by: Hikma Specialty USA Inc., Columbus, OH 43228.

This website is intended for U.S. audiences
Customer Service: Phone 1-800-631-2174 | Email

© Hikma Specialty USA Inc. All rights reserved.
NARCAN® is a registered trademark of Emergent Operations Ireland Limited.

KLOXXADO®️ is a registered trademark of Hikma Pharmaceuticals USA Inc.
The brand statement “Better Health. Within Reach. Every Day.” is a registered trademark of Hikma Pharmaceuticals PLC.

HK-1266-v3

June 2023

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Important Safety Information About KLOXXADO® (naloxone HCl) Nasal Spray 8 mg

Contraindications