Physicians & Prescribers2024-02-22T21:49:03-05:00

Physicians & Prescribers

Opioid overdose can happen to anyone.
Help your patients be ready with Kloxxado® (naloxone HCl) nasal spray 8 mg.

Prescribe a lifeline with twice the naloxone

78% of opioid overdoses involve at least 8 mg of naloxone.1 Kloxxado® is the only nasal spray that contains a full 8 mg in a single dose.2

  • 2x more naloxone per device as Narcan®2,3
  • Safe, portable and easy to have on hand2
  • A simple step to prevent accidental death by opioid overdose2

Study: A case for higher-dose naloxone

This recent study found that 78% of opioid overdose reversals required multiple doses of Narcan® Nasal Spray 4 mg, which suggests the need for a naloxone nasal spray that contains 8 mg of naloxone in a single dose.1

The increasing prevalence of highly potent, illicitly manufactured fentanyl and its analogues (IMF) in the USA is exacerbating the opioid epidemic which has worsened during the COVID-19 pandemic. Narcan® (naloxone HCl) Nasal Spray has been approved by the US Food and Drug Administration as a treatment for opioid-related overdoses. Due to the high potency of IMF, multiple naloxone administrations (MNA) may be needed per overdose event. It is essential to determine the patterns of naloxone use, including MNA, and preferences among bystanders who have used naloxone for opioid overdose reversal.

A cross-sectional web-based survey was administered to 125 adult US residents who administered 4 mg Narcan® Nasal Spray during an opioid overdose in the past year. The survey asked about the most recent overdose event, the use of Narcan® during the event and the associated withdrawal symptoms, and participant preferences regarding dosages of naloxone nasal spray. An open-ended voice survey was completed by 35 participants.

Most overdose events (95%) were successfully reversed, with 78% using ≥ 2 doses and 30% using ≥ 3 doses of Narcan® Nasal Spray. Over 90% were worried that 1 Narcan® box may not be enough for a successful future reversal. Reported withdrawal symptoms were similar in overdose events where 1 versus ≥ 2 sprays were given. Eighty-six percent of participants reported more confidence in an 8 mg versus a 4 mg naloxone nasal spray and 77% reported a stronger preference for 8 mg over 4 mg.

MNA occurred in most overdose events, often involving more sprays than are provided in one Narcan® nasal spray box, and participants predominantly expressed having a stronger preference for and confidence in an 8 mg compared to a 4 mg nasal spray. This suggests the need and desire for a higher dose naloxone nasal spray formulation option. Given that bystanders may be the first to administer naloxone to someone experiencing an opioid overdose, ensuring access to an adequate naloxone supply is critical in addressing the opioid overdose epidemic.

Life Saving Confidence

The following video captures voices of real people who have experience using naloxone HCl nasal spray 4 mg.1 Watch now.

What do the experts say about naloxone?

Kloxxado® Co-Rx Guide

Kloxxado® Co-Rx Guide

Download a quick guide to co-prescribing Kloxxado®.

Which patients need Kloxxado®?

Certain factors can increase a patient’s risk for opioid overdose. Co-prescribing naloxone is recommended for patients who are taking opioids and meet any of the following criteria:4

  • Taking opioids at a high strength (≥50MME/day)* or as a long-term therapy4
  • Taking a benzodiazepine4
  • Have certain respiratory conditions, like COPD or sleep apnea4
  • Have a mental health disorder4
  • Have a history of overdose or substance use disorder, including PWUD and patients in recovery4

How do I talk to my patients about Kloxxado®?

Just like wearing a seat belt or keeping a fire extinguisher, carrying Kloxxado® is an important safety measure for anyone who takes opioids. But starting the conversation around naloxone and opioid safety isn’t always easy.

Here are some helpful tips for talking to patients about their risk for accidental opioid overdose and how Kloxxado® can help in case of an emergency.

Choose the Right Language

A stigma is often attached to opioid use, and many patients don’t believe they’re at risk for overdose.5

Try This:

“Our standard of care is to provide naloxone to any patient on opioids, no matter the dose.”

“Naloxone is a safe and effective antidote to opioid overdoses, including those involving fentanyl.”

“Accidental overdose could happen if someone in your home, like a child, takes the medication by accident. Or if you accidentally take double the dose.”

Explain the Benefits

Help patients understand how Kloxxado® can help save a life from accidental overdose. Address any cost concerns.2

Try This:

“Having Kloxxado® nasal spray in the home is just a precaution. It’s like an EpiPen. But in the event of an accidental overdose, it could save a life.”

“Let me check the price of Kloxxado® nasal spray with your insurance or the Kloxxado® savings card.”

Help Patients Feel Prepared

Talk to patients about what an opioid overdose emergency looks like. Explain how to use and store Kloxxado®.

Try This:

“Kloxxado® nasal spray is easy to use. In the event of an opioid overdose emergency, follow these four simple steps. Then call 911.”

“Let’s review how to recognize an opioid overdose.”

“I recommend keeping Kloxxado® in your home in case of an emergency. Make sure family and friends know where it’s stored.”

The deadly risks of counterfeit pills.

Today, fentanyl is laced into fake pills that are made to look like OxyContin®, Xanax®, Adderall® and other pharmaceuticals.6 DEA lab testing found that 60% of fake pills with fentanyl contained a potentially lethal dose.6

  • It only takes a very small dose of fentanyl (2mg) to be lethal.6
  • It’s difficult to distinguish between a fake pill and a real one.6
  • Having naloxone on hand in case of an opioid overdose emergency is more critical than ever.7

More potent opioids, like fentanyl, may require more naloxone to counteract.7 That’s why Kloxxado® contains 8 mg of naloxone per device – the highest dose of naloxone available as a nasal spray.2

Relapse should be a learning experience, not a death sentence.

Kloxxado® is an important safety net for your patients who may have a substance use disorder (SUD).

SUD patients are at a high risk of overdose due to a diminished tolerance to opioids.8

  • 40-60% of SUD patients in recovery will experience a relapse.8
  • If they relapse on their previously “normal” opioid dose, they could be more likely to experience an overdose.8
  • Fentanyl is particularly dangerous for someone with less tolerance to opioids.9 It can be mixed with other drugs like pills, heroin, cocaine and meth without the user’s knowledge.9

Talk to your patients about their risks and prescribe Kloxxado® so they can be prepared.

Request a Kloxxado® Training Kit

The Kloxxado® Training Kit includes helpful resources for your patients, including a training device and Kloxxado® Savings Cards.

Kloxxado® Co-Rx Guide

Kloxxado® Co-Rx Guide

Download a quick guide to co-prescribing Kloxxado®.


  1. Abdelal R, Banerjee A, Carlberg-Racich S, Darwaza N, Ito D, Shoaff J, Epstein J. Real-World Study of Multiple Naloxone Administration for Opioid Overdose Reversal Among Bystanders. JMCP. 2021;27(10-a):S54.
  2. KLOXXADO® (naloxone HCl) Nasal Spray [prescribing information]. Columbus, OH: Hikma Specialty USA Inc., 2021.
  3. NARCAN® (naloxone HCl) Nasal Spray [prescribing information]. Plymouth Meeting, PA: Emergent BioSolutions, 2020.
  4. Naloxone: The Opioid Reversal Drug that Saves Lives. US Department of Health and Human Services website. Available at: Accessed June 25, 2023.
  5. Cheetham A, Picco L, Barnett A, Lubman DI, Nielsen S. The Impact of Stigma on People with Opioid Use Disorder, Opioid Treatment, and Policy. Subst Abuse Rehabil. 2022;13:1-12.
  6. One Pill Can Kill Fake Pills Fact Sheet. US Drug Enforcement Agency website. Available at: Accessed June 25, 2023.
  7. Naloxone DrugFacts. National Institute on Drug Abuse website. Available at: Accessed June 25, 2023.
  8. Drugs, Brains, and Behavior: The Science of Addiction/Treatment and Recovery. National Institute on Drug Abuse website. Available at: Accessed June 26, 2023.
  9. Fentanyl DrugFacts. National Institute on Drug Abuse website. Available at: Accessed June 26, 2023.
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Important Safety Information About KLOXXADO® (naloxone HCl) Nasal Spray 8 mg