Why Kloxxado™ (naloxone HCl) nasal spray 8 mg

Naloxone can reverse the effects of opioid overdose

Naloxone — the medicine in Kloxxado™ — plays a vital role in the fight against opioid addiction and overdose. It’s been the main antidote to opioid overdoses for more than 50 years.1

Naloxone can counteract the life-threatening effects of an opioid overdose, allowing an overdose victim to regain their ability to breathe normally again.2

The medication only works if a person has opioids in their system and has no effect if opioids are not present. So administering naloxone isn’t likely to harm someone but it could save their life.2

Keep Kloxxado™ as part of your first aid kit

Just like a car crash or house fire, you’ll never see it coming. But you can do one simple thing to prevent an accidental opioid overdose3 from being fatal. Keep yourself, your family and your friends prepared. Keep Kloxxado™ (naloxone HCl) nasal spray nearby as part of your first aid kit.


There’s no time for half measures

Overdoses involving highly potent opioids may require more naloxone to reverse.4 Kloxxado™ contains more naloxone per dose.5 In fact, Kloxxado™ contains twice as much naloxone per spray than Narcan® (naloxone HCl) nasal spray 4 mg.6,7 This is important because 34% of opioid overdose reversals involve 2 or more doses of naloxone.8

Your doctor is ready to talk about Kloxxado™. Are you?

Trust your doctor. The idea of discussing the risks of opioid overdose may be uncomfortable, but your doctor is ready for it. Ask your doctor if your opioid dose calls for a prescription of naloxone.

How to use Kloxxado™

Be ready to take action. Kloxxado™ was designed to be used by anyone without the need for medical training.

Be Ready
kloxxado savings card

Kloxxado™ Savings Card

You could pay as little as $0* with the first-ever savings card for naloxone nasal spray.

Save Now


  1. Jordan, M.R. and Morrisonponce, D. 2021, “Naloxone,” StatPearls Publishing, https://pubmed.ncbi.nlm.nih.gov/28722939/, Accessed May 3, 2021.
  2. FDA 2019, “Having Naloxone on Hand Can Save a Life During an Opioid Overdose,” https://www.fda.gov/consumers/consumer-updates/having-naloxone-hand-can-save-life-during-opioid-overdose, Accessed May 3, 2021.
  3. FDA 2021, “Information about Naloxone,” https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/information-about-naloxone, Accessed June 1, 2021.
  4. NIDA 2021, “Naloxone DrugFacts,” National Institute on Drug Abuse, https://www.drugabuse.gov/publications/drugfacts/naloxone, Accessed May 3, 2021.
  5. CDC 2021, “Fentanyl,” https://www.cdc.gov/drugoverdose/opioids/fentanyl.html, Accessed May 3, 2021.
  6. KLOXXADO™ (naloxone HCl) Nasal Spray [prescribing information]. Columbus, OH: Hikma Specialty USA Inc., 2021
  7. NARCAN® (naloxone HCl) Nasal Spray [prescribing information]. Plymouth Meeting, PA: Emergent BioSolutions, 2020
  8. Avetian et. al. 2018, “Use of naloxone nasal spray 4mg in the community setting: a survey of use by community organizations”, Current Medical Research and Opinion, 34(4):573-576.

*Maximum value of $40 per box. The Kloxxado™ Savings card is not Health Insurance. See complete eligibility and restrictions.