Community Organizations2023-08-22T17:03:04-04:00

Community Organizations

Illicitly manufactured fentanyl and other synthetic opioids have taken over.1 Fight back with more naloxone: Kloxxado® (naloxone HCl) Nasal Spray 8 mg.2

Equip your community with Kloxxado®

Kloxxado® (naloxone HCl) 8 mg contains the most naloxone available in a nasal spray and works quickly to reverse an opioid overdose.2,3

  • 2x more naloxone per device as Narcan® (naloxone HCl) Nasal Spray 4 mg2,3
  • 2x medicine per box than Narcan®2,4
  • Effective counter to fentanyl overdose2
  • Community pricing and bulk orders available

The MORE Study: A case for higher-dose naloxone

This recent study found that 78% of opioid overdose reversals required multiple doses of Narcan® Nasal Spray 4 mg, which suggests  the need for a naloxone nasal spray that contains 8 mg of naloxone in a single dose.1

The increasing prevalence of highly potent, illicitly manufactured fentanyl and its analogues (IMF) in the USA is exacerbating the opioid epidemic which has worsened during the COVID-19 pandemic. Narcan® (naloxone HCl) Nasal Spray has been approved by the US Food and Drug Administration as a treatment for opioid-related overdoses. Due to the high potency of IMF, multiple naloxone administrations (MNA) may be needed per overdose event. It is essential to determine the patterns of naloxone use, including MNA, and preferences among bystanders who have used naloxone for opioid overdose reversal.

A cross-sectional web-based survey was administered to 125 adult US residents who administered 4 mg Narcan® Nasal Spray during an opioid overdose in the past year. The survey asked about the most recent overdose event, the use of Narcan® during the event and the associated withdrawal symptoms, and participant preferences regarding dosages of naloxone nasal spray. An open-ended voice survey was completed by 35 participants.

Most overdose events (95%) were successfully reversed, with 78% using ≥ 2 doses and 30% using ≥ 3 doses of Narcan® Nasal Spray. Over 90% were worried that 1 Narcan® box may not be enough for a successful future reversal. Reported withdrawal symptoms were similar in overdose events where 1 versus ≥ 2 sprays were given. Eighty-six percent of participants reported more confidence in an 8 mg versus a 4 mg naloxone nasal spray and 77% reported a stronger preference for 8 mg over 4 mg.

MNA occurred in most overdose events, often involving more sprays than are provided in one Narcan® nasal spray box, and participants predominantly expressed having a stronger preference for and confidence in an 8 mg compared to a 4 mg nasal spray. This suggests the need and desire for a higher dose naloxone nasal spray formulation option. Given that bystanders may be the first to administer naloxone to someone experiencing an opioid overdose, ensuring access to an adequate naloxone supply is critical in addressing the opioid overdose epidemic.

Life Saving Confidence

The following video captures voices of real people who have experience using naloxone HCl nasal spray 4 mg.1 Watch now.

Help reduce opioid overdose deaths

Illicitly-manufactured fentanyl is everywhere and in everything.1 One of the biggest risk factors is that people are often exposed unintentionally.1

Overdoses involving synthetic opioids and other drugs are a growing concern. Synthetic opioids were involved in:

  • 71% of cocaine-involved deaths4
  • 65% of benzodiazepine-involved deaths4
  • 49% of stimulant-involved deaths4
  • 43% of antidepressant-involved deaths4

Fentanyl is often laced into fake pills that are made to look like OxyContin®, Xanax®, Adderall® and other pharmaceuticals.1 In fact, DEA lab testing found that 60% of fake pills with fentanyl contained a potentially lethal dose.1

Community groups and harm-reduction organizations are at the front lines of this evolving epidemic, offering care and hope to hundreds of individuals.

To help improve access to naloxone and support the important work that you do, we offer special pricing on bulk orders of Kloxxado®. Contact us to learn more.

62% of all overdose deaths are attributed to fentanyl4

Overcoming opioid overdose takes stronger medicine

Get community pricing on Kloxxado®

Kloxxado® naloxone nasal spray is available at a discounted price for qualified community-based organizations and public entities. It may already be available through your state program. Contact us to learn more about pricing, how to place an order, and how to work with your state to ensure Kloxxado® is available for your community.

Community Factsheet

Find out why your community may need more naloxone.


  1. Fake Pills Fact Sheet. US Drug Enforcement Administration website. Available at: Accessed June 27, 2023.
  2. KLOXXADO® (naloxone HCl) Nasal Spray [prescribing information]. Columbus, OH: Hikma Specialty USA Inc., 2021.
  3. NARCAN® (naloxone HCl) Nasal Spray [prescribing information]. Plymouth Meeting, PA: Emergent BioSolutions, 2020.
  4. Drug Overdose Death Rates. National Institute on Drug Abuse website. Available at: Accessed June 27, 2023.
  5. Abdelal R, Banerjee A, Carlberg-Racich S, Darwaza N, Ito D, Shoaff J, Epstein J. Real-World Study of Multiple Naloxone Administration for Opioid Overdose Reversal Among Bystanders. JMCP. 2021;27(10-a):S54.
  6. Non-Fatal Opioid Overdose and Associated Health Outcomes: Final Summary Report. ASPE website. Available at: Accessed June 25, 2023.
  7. Mell, Howard K et al., 2017. “Emergency Medical Services Response Times in Rural, Suburban, and Urban Areas.” JAMA Surgery, 152(10), 983–984.

* Maximum value of $40 per box, up to 2 boxes per redemption, up to 4 boxes per month. No activation is necessary. See eligibility and restrictions.

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Important Safety Information About KLOXXADO® (naloxone HCl) Nasal Spray 8 mg