Co-prescribing naloxone is recommended for your patients who are taking opioids and:7,8

  • At a high strength​ (e.g., ≥ 50MME/day)* or as a long-term therapy
  • With a benzodiazepine
  • Have certain respiratory conditions, like COPD or sleep apnea
  • Have a mental health disorder
  • Have a history of overdose or substance use disorder, including PWUD and patients in recovery
  • Are likely to observe an overdose among family, friends, or caregivers​

Download the Kloxxado™ Co-RX Guide for more details.


* Your state PDMP may have built-in tools to help you assess a patient’s MME-associated risks.