A second dose of Kloxxado™ nasal spray may be necessary. One dose of naloxone may not be enough to reverse the effects of an opioid overdose that involves strong opioids. Or, sometimes, the naloxone dose can wear off before the opioids—necessitating another dose.2

Emergency medical services (EMS) should be called immediately after administering the first dose and will hopefully arrive before a second dose is needed. But if help hasn’t arrived, bystanders can administer additional doses of Kloxxado™ nasal spray every 2 to 3 minutes in alternating nostrils if the patient doesn’t respond, responds insufficiently or relapses back into respiratory depression.2

Get emergency medical help right away in any cases of known or suspected overdose emergency. Kloxxado™ nasal spray is not a substitute for emergency medical care.2 Administer in accordance with the Instructions for Use. See Kloxxado™ Quick Instructions for Use.