Here’s what you need to know about Kloxxado®

For the first time in five years, data from the Centers for Disease Control show a slight reduction in the number of opioid overdose deaths from one year to the next (a 3% decrease was reported between 2022 and 2023).1 But make no mistake—in spite of this small downturn in opioid overdose-related fatalities, fentanyl remains the nation’s greatest and most urgent drug threat.2 According to the US Drug Enforcement Administration, fentanyl and other synthetic opioids are responsible for about 70% of drug-related deaths.2 So what can you do to protect yourself and others from the dangers of opioid overdose? Carry a naloxone product like Kloxxado.®3 When given in time, Kloxxado® can reverse the effects of an overdose from opioids including fentanyl, heroin and prescription opioid medicines.3,4 Read on to find out where to get the opioid overdose antidote Kloxxado®, as well as answers to other questions you may have about this life-saving medication.3

Why do I need Kloxxado®?

Fentanyl, a drug that is about 50 times stronger than heroin and about 100 times stronger than morphine, seems to be everywhere—it’s even laced into other non-opioid drugs.5 In fact, one of the biggest risk factors for opioid overdose is coming into contact with illicit fentanyl unintentionally.5 Drug dealers sometimes mix fentanyl in with other substances (cocaine and methamphetamines, for example) without the user’s knowledge.6-8 Fentanyl often is added to other drugs because of its extreme potency, which makes the resulting product cheaper, more powerful, more addictive and more dangerous.8 The rising rate of drug overdoses—especially those involving synthetic opioids mixed with other drugs—is a cause for concern.6,7 According to 2022 data from the National Institute on Drug Abuse, synthetic opioids (other than methadone) were involved in:6,7

  • 75% of cocaine-involved deaths
  • 68% of benzodiazepine-involved deaths
  • 68% of stimulant-involved deaths
  • 47% of antidepressant-involved deaths

How is Kloxxado® different from Narcan® (Naloxone HCl) Nasal Spray 4 mg?

Although Kloxxado® and Narcan® contain the same active ingredient — naloxone — it’s important to understand that the two products are not the same.3,9 Kloxxado®, a prescription medication, contains 8 mg of naloxone per device, while Narcan® contains 4 mg.3,9 This distinction is important because 78% of opioid overdose reversals involved at least two 4-mg doses of naloxone.10

Why should I consider Kloxxado®?

To prevent death from opioid overdose, you must get enough naloxone into a person’s bloodstream to reach the brain and reverse the effects of the opioid.11 Timing is also important because fentanyl is so powerful—an overdose can set in within minutes or even seconds.12 Although overdoses involving fentanyl require a fast response, Emergency Medical Response (EMS) times unfortunately can vary.13 The average EMS response time ranges from about seven minutes in urban areas to about 14 and a half minutes in rural areas.13

When should I use Kloxxado®?

An opioid overdose can happen to anyone, at any time. Opioid overdoses do not have to be fatal, however. One study found that bystanders were present in more than one in three overdoses involving opioids.4 That’s why it’s so important to always be prepared. If you suspect that someone is suffering an opioid overdose, give them naloxone right away and then call 911.3 If the person is not experiencing an opioid overdose but is unconscious as a result of some other medical emergency (diabetic coma or cardiac arrest, for example), naloxone generally will not have any effect or cause additional harm.14

Where can I get Kloxxado®?

Just like a car accident or house fire, you never know when you might come face to face with an opioid overdose situation. And just like you wear a seatbelt in the car and keep a fire extinguisher in your home, you can protect yourself and others from opioid overdose by keeping Kloxxado® close at hand. Ask your doctor if Kloxxado® is right for you. Kloxxado® is a prescription medication that is available at retail pharmacies across the United States. If your regular pharmacy doesn’t keep Kloxxado® on the shelf, they may be able to order it for you. If you get your naloxone from a community program, ask them if they distribute (or might consider distributing) Kloxxado®.

image of US map

When given in time, Kloxxado® is a life-saving naloxone product that can reverse the effect of an opioid overdose. You can get it at retail pharmacies across the US.

How do I use Kloxxado®?

With Kloxxado®, practically anyone can reverse an opioid overdose, and possibly with just one dose.3 Once administered, Kloxxado® works in the brain, right at the opioid receptor, to potentially reverse the deadly effects of the opioid causing the overdose.3,15 When a life-threatening opioid overdose happens, give the person Kloxxado® and then call 911.3 Kloxxado® is not a substitute for emergency medical care.3

Just 4 Simple Steps4

How can I get Kloxxado® for my organization?

If you are interested in placing a bulk order of Kloxxado® for your organization, public access pricing may be available. Get in touch with a Hikma Pharmaceuticals account representative via the order inquiry form or call Hikma Customer Service at 1-877-259-6893. If you are affiliated with a harm reduction program or similar organization that would benefit from an uninterrupted supply of naloxone, you may wish to get Kloxxado® through KloxxadoDirectTM.

How much does Kloxxado® cost?

With the Kloxxado® Savings Card (the first manufacturer’s savings card for a naloxone nasal spray), individuals could pay as little as $0* (up to $40 savings for eligible patients) for Kloxxado® nasal spray. It takes only minutes to download a Kloxxado® Savings Card to use at the pharmacy. You can download a Card by clicking here. To use the Card, bring it to the pharmacy with your prescription for Kloxxado®. No activation is necessary, and the Card may enable you to pay as little as $0 per box, up to 2 boxes per redemption, up to 4 boxes per month.

*Maximum value of $40 per box. The Kloxxado® Savings Card is not health insurance. See complete eligibility and restrictions at Kloxxado.com.

Kloxxado® is a registered trademark of Hikma Pharmaceutals USA Inc.

All other registered trademarks are the property of their respective owners.

Please see the Full Prescribing Information and Medication Guide for Kloxxado® for complete product details.

NOTE: This article was not written by a medical professional and is not intended to substitute for the guidance of a physician. These are not Hikma’s recommendations, but rather facts and data collected from various reliable medical sources. For a full list of resources and their attributing links, see below.

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References

  1. US Overdose Deaths Decrease in 2023, First Time Since 2018. CDC National Center for Health Statistics website. Available at: https://www.cdc.gov/nchs/pressroom/nchs_press_releases/2024/20240515.htm. Accessed June 10, 2024.
  2. DEA Releases 2024 National Drug Threat Assessment. US Drug Enforcement Administration website. Available at: https://www.dea.gov/press-releases/2024/05/09/dea-releases-2024-national-drug-threat-assessment. Accessed June 10, 2024.
  3. Kloxxado® (naloxone HCl) Nasal Spray [prescribing information]. Columbus, OH: Hikma Specialty USA Inc., 2021.
  4. Lifesaving Naloxone. US Centers for Disease Control and Prevention website. Available at: https://www.cdc.gov/stop-overdose/caring/naloxone.html. Accessed May 13, 2024.
  5. Fake Prescription Pills. US Drug Enforcement Administration website. Available at: https://www.dea.gov/factsheets/fake-prescription-pills. Accessed May 15, 2024.
  6. Drug Overdose Death Rates. National Institutes of Health/National Institute on Drug Abuse website. Available at: https://nida.nih.gov/research-topics/trends-statistics/overdose-death-rates. Accessed May 16, 2024.
  7. National Drug Overdose (OD) Deaths, 1999-2022. CDC Wonder, Multiple Cause of Death (Detailed Mortality). Available at: https://view.officeapps.live.com/op/view.aspx?src=https%3A%2F%2Fnida.nih.gov%2Fsites%2Fdefault%2Ffiles%2Foverdose_data_1999-2022_5.2.2024.xlsx&wdOrigin=BROWSELINK. Accessed May 16, 2024.
  8. Fentanyl Facts. Stop Overdose/US Centers for Disease Control and Prevention website. Available at: https://www.cdc.gov/stop-overdose/caring/fentanyl-facts.html?CDC_AAref_Val=https://www.cdc.gov/stopoverdose/fentanyl/index.html. Accessed May 15, 2024.
  9. Narcan® (naloxone HCl) nasal spray 4 mg [prescribing information]. Plymouth Meeting, PA: Emergent Devices Inc.; 2021.
  10. Abdelal R, Banerjee R, et al. Real-world study of multiple naloxone administration for opioid overdose reversal among bystanders. Harm Reduct J. 2022. 19:49.
  11. Dahan A, et al. 2024, “Fact vs. fiction: naloxone in the treatment of opioid-induced respiratory depression in the current era of synthetic opioids.” Front Public Health. 12:1346109.
  12. Somerville NJ et al. Characteristics of Fentanyl Overdose—Massachusetts, 2014-2016. MMWR. 2017;66(14):382-386.
  13. Mell, H.K. et. Al. 2017, “Emergency Medical Services Response Times in Rural, Suburban, and Urban Areas,” JAMA Surg, doi:10.1001/jamasurg.2017.2230.
  14. Access to Naloxone Can Save a Life During an Opioid Overdose. US Food and Drug Administration website. Available at: https://www.fda.gov/consumers/consumer-updates/access-naloxone-can-save-life-during-opioid-overdose. Accessed April 19, 2024.
  15. Naloxone DrugFacts. National Institute on Drug Abuse website. Available at: https://nida.nih.gov/publications/drugfacts/naloxone. Accessed May 13, 2024.