How to Get KLOXXADO®

How to Get KLOXXADO®2025-04-28T15:17:52-04:00

Getting KLOXXADO® is simple and easy

An opioid overdose emergency can happen to anyone, at any time – ask your doctor if prescription KLOXXADO® is right for you.

KLOXXADO® is available at retail pharmacies across the United States. If your pharmacy of choice doesn’t have it on the shelf, they can get it for you quickly. If you get your naloxone from a community program, ask them if they distribute (or can start distributing) KLOXXADO®.

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Prescribers

For patients at risk of opioid overdose, naloxone is key. Discuss if KLOXXADO®—an 8mg option—is appropriate.

Learn more

Pharmacists

KLOXXADO® can save your patient’s life, and there is no generic equivalent. Be sure to keep it on the shelf.

Stock KLOXXADO®

Buy in Bulk

Community pricing is available for community organizations and first responders.

Visit KLOXXADODirect™

Tips for Getting KLOXXADO®

Keeping KLOXXADO® on hand is one more way to be prepared for an opioid overdose emergency. KLOXXADO® offers 8 mg of naloxone – a higher dose for situations where more may be needed.*

* The clinical significance of a higher dose is currently unknown.

  • At the pharmacy counter, ask for KLOXXADO® by name.
  • If KLOXXADO® is not on the shelf at your preferred pharmacy, they can order it for you (may take 1-2 days).
  • Some states require a naloxone prescription, so it’s best to check with your doctor or pharmacist first.
  • If you get your naloxone from a community program or harm reduction program, ask them if they can get KLOXXADO® for your community.

Get answers to other common questions about getting KLOXXADO® below.

How do I talk to my doctor about KLOXXADO®?2025-04-21T17:39:26-04:00

The idea of discussing the risks of opioid overdose may be uncomfortable, but your doctor is ready for it. If you think there is a risk for you or your family, talk to your doctor about a KLOXXADO® prescription.

Anyone taking opioids could be at risk for accidental opioid overdose. You may be at a higher risk of accidental overdose if you take opioids and:

  • Have a history of overdose or a substance use disorder (SUD)
  • Have sleep apnea or other sleep-disordered breathing
  • Are taking higher dosages of opioids (e.g., ≥50 MME/day)
  • Are returning to a high dose after losing tolerance (e.g., patients undergoing tapering or recently released from prison)
  • Take benzodiazepines with opioids
  • Have kidney or liver failure
  • Are 65 years and older

* Opioids/Risks and How to Reduce Them. Centers for Disease Control and Prevention website. Available at: https://www.cdc.gov/opioids/patients/reduce-risks.html. Accessed June 23, 2023

Do I need a prescription to get KLOXXADO®?2025-03-13T23:33:45-04:00

KLOXXADO® is a prescription medication available at retail pharmacies across the U.S. Talk to your doctor to find out if KLOXXADO® is right for you. Depending on your state, KLOXXADO® may also be available through a standing order. Check with your state to see if this applies.

Is KLOXXADO® Nasal Spray covered by insurance?2025-04-21T17:40:22-04:00

KLOXXADO® is covered by many health insurance plans, including most Medicaid programs. Contact your insurance provider to learn more.

Where can I get KLOXXADO® Nasal Spray?2025-03-13T23:39:00-04:00

KLOXXADO® is a prescription medicine. KLOXXADO® Nasal Spray is available at your local pharmacy with a prescription from your doctor. Ask your doctor if a prescription for naloxone is right for you. Depending on your state, KLOXXADO® may also be available through a standing order. Check with your state to see if this applies.

Organizations wishing to order KLOXXADO® Nasal Spray:

Qualified public entities such as government entities, first responders, community organizations, schools and universities can purchase at a discounted price through KLOXXADODirect™.

The Opioid Epidemic

With the spread of illegally-made, synthetic opioids like fentanyl, overdose deaths have grown across ages, races, ethnicities and communities.

Facts About Fentanyl

Facts About Fentanyl

Extremely potent, illegally-made synthetic opioids such as fentanyl and carfentanil are the most common drugs involved in overdose deaths in the United States.

Understanding Overdose

Understanding Overdose

More than a million Americans will die this decade of an opioid overdose. You could save someone.

KLOXXADO® Quick Use Instructions

Easy-to-follow instructions for administering KLOXXADO®.

See More Resources ›

Important Safety Information About KLOXXADO® (naloxone HCl) Nasal Spray 8 mg

Contraindications

Hypersensitivity to naloxone hydrochloride or to any of the other ingredients

Warnings and Precautions

  • Use KLOXXADO® right away if you suspect an opioid overdose emergency, even if you are not sure, because an opioid overdose emergency can cause severe injury or death. Signs and symptoms of an opioid overdose emergency may include:
    • Unusual sleepiness; you are not able to awaken the person with a loud voice or by rubbing firmly on the middle of their chest (sternum).
    • Breathing problems, including slow or shallow breathing in someone difficult to awaken or who looks like they are not breathing.
    • The black circle in the center of the colored part of the eye (pupil) is very small (sometimes called “pinpoint pupils”) in someone difficult to awaken.
  • Family members, caregivers or other people who may have to use KLOXXADO® in an opioid overdose emergency should know where KLOXXADO® is stored and how to give KLOXXADO® before an opioid overdose emergency happens.
  • Get emergency medical help right away after using the first dose of KLOXXADO®. Rescue breathing or CPR (cardiopulmonary resuscitation) may be needed while waiting for emergency medical help.
  • The signs and symptoms of an opioid overdose emergency can return after KLOXXADO® is given. If this happens, give another dose after 2 to 3 minutes, using a new KLOXXADO® device, alternating nostrils, and watch the person closely until emergency medical help arrives.
  • Do not use KLOXXADO® if you are allergic to naloxone hydrochloride or any of the ingredients in KLOXXADO®.
  • KLOXXADO® can cause sudden and severe opioid withdrawal, the symptoms of which may include body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goosebumps, sweating, yawning, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramps, weakness and increased blood pressure.
  • In infants under 4 weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.
  • Tell your doctor about all of your medical conditions before using KLOXXADO®, including if you have heart problems, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed.
  • Tell your doctor about all of the medicines you take, including prescription drugs and over-the-counter medicines, drugs, vitamins and herbal supplements.

Side Effects

The following serious side effect is discussed in the full Prescribing Information for KLOXXADO®:

  • Sudden and Severe Opioid Withdrawal

Symptoms of sudden and severe opioid withdrawal resulting from the use of KLOXXADO® in someone regularly using opioids include: body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goosebumps, sweating, yawning, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramps, weakness and increased blood pressure.

Infants may have seizures, cry more than normal and have increased reflexes.

Some people may become aggressive after abrupt reversal of opioid overdose.

In two clinical studies, a total of 47 healthy adult volunteers were exposed to a single dose of KLOXXADO®, one spray in one nostril. Side effects were reported in two subjects for each of the following: abdominal pain, asthenia, dizziness, headache, nasal discomfort, and presyncope.

These are not all of the possible side effects of KLOXXADO®. Contact your doctor for medical advice about side effects.

Pregnancy, Infancy and Breastfeeding, Children

Tell your doctor if you are pregnant or plan to become pregnant. If you are pregnant and opioid dependent, use of KLOXXADO® may cause withdrawal symptoms in you and your unborn baby. A healthcare provider should monitor you and your unborn baby right away after you use KLOXXADO®.

There is no information regarding the presence of naloxone in human milk, the effects of naloxone on the breastfed infant or on milk production.

If the primary concern is an infant at risk of an overdose, consider whether other naloxone-containing products may be more appropriate.

KLOXXADO® nasal spray is safe and effective in children for known or suspected opioid overdose.

Dosage and Administration

Do not attempt to prime or test-fire the device. Each KLOXXADO® Nasal Spray contains only 1 dose of medicine and cannot be reused. Read the “instructions for use” at the end of the Prescribing Information and Medication Guide for detailed information about the right way to use KLOXXADO® Nasal Spray.

Storage and Handling

Store KLOXXADO® at room temperature between 68°F to 77°F (20°C to 25°C). Do not expose to temperatures below 41°F (5°C) or above 104°F (40°C). Do not freeze KLOXXADO®. Keep KLOXXADO® in its box until ready to use. Protect from light. Replace KLOXXADO® before the expiration date on the box. Keep KLOXXADO® and all medicines out of the reach of children.

For more information, please see the full Prescribing Information and Medication Guide.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch or call 1-800-FDA-1088.

This website is intended for U.S. audiences
Customer Service: Phone 1-800-631-2174 | Email

© Hikma Pharmaceuticals USA Inc. All rights reserved.

KLOXXADO®️ is a registered trademark of Hikma Pharmaceuticals USA Inc.
Better Health. Within Reach. Every Day.®️ is a registered trademark of Hikma Pharmaceuticals PLC.
Emergent Devices Inc. is wholly owned subsidiary of Emergent BioSolutions Inc.
KLOXXADO® is manufactured by Hikma Pharmaceuticals USA Inc., Columbus, OH 43228, and distributed by Emergent Devices Inc., Plymouth Meeting, PA 19462.

PP-KLOX-US-00024

March 2025

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Important Safety Information About KLOXXADO® (naloxone HCl) Nasal Spray 8 mg

Contraindications