Let’s Compare: Kloxxado® vs Narcan®

Let’s Compare: Kloxxado® vs Narcan®2023-07-27T16:39:38-04:00

Comparing Kloxxado® (naloxone HCl) nasal spray 8 mg vs Narcan® (naloxone HCl) Nasal Spray 4 mg and Other Naloxone Offerings

Drug overdose is the leading cause of accidental death in the US, and the majority involve opioids.1 Illicitly manufactured fentanyl, a synthetic opioid which is 50 times stronger than heroin, is a major contributor to this wave of opioid overdose deaths.2 A fentanyl overdose can set in within minutes or even seconds.3,4 More than 150 people die each day from overdoses involving illicitly manufactured synthetic opioids like fentanyl.2

Medicines containing naloxone can safely reverse opioid overdose—even overdoses that involve fentanyl.5 Naloxone does this by attaching to the opioid receptors in the brain to stop the effects of opioids.6 This can help the person start breathing again.6 A naloxone nasal spray, such as Kloxxado® (naloxone HCl) nasal spray 8 mg, can be given to an overdose victim right at the scene by anyone—even if they have no medical training.7,8 Injectable forms of naloxone are available as well.9-11

Forty percent of fatal overdoses occur with someone nearby.12 If you come across someone experiencing an opioid overdose, and you’re carrying naloxone, you may be able to save that person’s life.5 (Click here to learn more about how to recognize an opioid overdose emergency.)

Naloxone is available in many forms, including Kloxxado® and 4 others shown below.7-11 If you’re thinking about carrying naloxone, here is a side-by-side comparison with Kloxxado® so you can decide which one(s) you would feel most comfortable giving in an emergency.


of fatal overdoses occur with someone nearby.12

Accidental opioid overdose is more common than you think

Accidental drug overdose is the leading cause of accidental death in the US. Most of these involve opioids.3

Opioid medications used for pain are generally safe when taken for a short time and accounting for your own risk factors as prescribed by a doctor.2 But accidents can happen. You could accidentally take more than recommended. Your medicines may interact in ways you didn’t expect. You may have a medical condition that puts you at more risk than you thought. Someone could get into your medicine cabinet.4

The Bottom Line: Accidents Happen

Just like you wear your seatbelt and keep a fire extinguisher in your home, having Kloxxado® (naloxone HCl) nasal spray 8 mg in your first aid kit is a simple safety measure that could save your life.

Let your household members and friends know where to find Kloxxado® so they can help you in case of an emergency.

How to recognize an opioid overdose emergency

During an opioid overdose breathing can decline drastically or stop, causing brain damage and death. Check for the following signs of an opioid overdose so you can act fast:

Take control of your safety. Talk to your doctor about your risk factors. Be ready with Kloxxado®.

A bystander was present for nearly 40% of fatal overdoses.6

Take action right away

Take action if you suspect an opioid overdose emergency, even if you’re not sure. It could save someone’s life.


  1. CDC, “Preventing an Opioid Overdose,” https://www.cdc.gov/drugoverdose/pdf/patients/preventing-an-opioid-overdose-tip-card-a.pdf, Accessed June 1, 2021.
  2. NIDA 2021, “Prescription Opioid DrugFacts,”  https://www.drugabuse.gov/publications/drugfacts/prescription-opioids, Accessed June 1, 2021.
  3. National Safety Council, “Addressing the Opioid Crisis.” https://www.nsc.org/home-safety/safety-topics/opioids, Accessed May 3, 2021.
  4. Mayo Clinic Staff 2020, “Medication errors: Cut your risk with these tips,” https://www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/medication-errors/art-20048035, Accessed May 3, 2021.
  5. HHS 2019. “Non-fatal opioid overdose and associated health outcomes,” https://aspe.hhs.gov/basic-report/non-fatal-opioid-overdose-and-associated-health-outcomes-final-summary-report, Accessed May 2021.
  6. CDC, 2020, “Overdose Deaths and the Involvement of Illicit Drugs.” https://www.cdc.gov/drugoverdose/featured-topics/VS-overdose-deaths-illicit-drugs.html, Accessed September 15, 2021.
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Important Safety Information About KLOXXADO® (naloxone HCl) Nasal Spray 8 mg