Blog posts about Kloxxado® (naloxone HCl) Nasal Spray 8 mg.
Even though Kloxxado® (naloxone HCl) nasal spray 8 mg received FDA approval more than two years ago, it continues to get plenty of press. Kloxxado®, which contains twice as [...]
When you consider that it gets dark earlier, stress levels seem to be higher and the “holiday blues” are common, it’s not surprising that 81% of people who took [...]
A new phase of the fentanyl crisis in America Historically, the opioid epidemic in this country has been described as having three “waves.”1 Now, however, we appear to be [...]
Chronic pain is a debilitating condition that affects millions of Americans.1,2 It can impact all different aspects of a person’s life, and has been linked to depression as well [...]
If you’ve spent any time in a school, you probably know about the emergency procedures in place to keep students safe from threats like fires, tornadoes and earthquakes. But what about drugs in schools? Opioids specifically? According to the Centers for Disease Control and Prevention, opioids like fentanyl are claiming the lives of our nation’s kids at alarming rates.1,2 In 2021, for example, fentanyl was involved in 84% of all overdose deaths among teens.1 So what can parents and school administrators do to fight back? Treat opioids like other threats, and formulate an emergency plan that includes keeping naloxone in schools for opioid overdoses. Read on to learn more about how naloxone in schools saves lives.
Bars. Nightclubs. Concert venues. Parties on college campuses. What do they all have in common? They’re all places people go to be social and have a good time. Unfortunately, [...]
Here's what you need to know about Kloxxado® For the first time in five years, data from the Centers for Disease Control show a slight reduction in the number [...]
Myths about naloxone are common, so you need to get the facts. In this blog, learn more about life-saving naloxone and how it reverses the effects of opioids. What [...]
The United States is home to 574 ethnically, culturally and linguistically diverse federally recognized Tribal Nations.1 Due to a number of societal, economic and environmental factors, however, these communities [...]
Top 5 Reasons You Should Carry Kloxxado®, the Orange Naloxone Chances are, you know someone who has lost a friend or loved one to an accidental drug overdose or [...]
Contraindications
Hypersensitivity to naloxone hydrochloride or to any of the other ingredients
Warnings and Precautions
Side Effects
The following serious side effect is discussed in the full Prescribing Information for KLOXXADO®:
Symptoms of sudden and severe opioid withdrawal resulting from the use of KLOXXADO® in someone regularly using opioids include: body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goosebumps, sweating, yawning, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramps, weakness and increased blood pressure.
Infants may have seizures, cry more than normal and have increased reflexes.
Some people may become aggressive after abrupt reversal of opioid overdose.
In two clinical studies, a total of 47 healthy adult volunteers were exposed to a single dose of KLOXXADO®, one spray in one nostril. Side effects were reported in two subjects for each of the following: abdominal pain, asthenia, dizziness, headache, nasal discomfort, and presyncope.
These are not all of the possible side effects of KLOXXADO®. Contact your doctor for medical advice about side effects.
Pregnancy, Infancy and Breastfeeding, Children
Tell your doctor if you are pregnant or plan to become pregnant. If you are pregnant and opioid dependent, use of KLOXXADO® may cause withdrawal symptoms in you and your unborn baby. A healthcare provider should monitor you and your unborn baby right away after you use KLOXXADO®.
There is no information regarding the presence of naloxone in human milk, the effects of naloxone on the breastfed infant or on milk production.
If the primary concern is an infant at risk of an overdose, consider whether other naloxone-containing products may be more appropriate.
KLOXXADO® nasal spray is safe and effective in children for known or suspected opioid overdose.
Dosage and Administration
Do not attempt to prime or test-fire the device. Each KLOXXADO® Nasal Spray contains only 1 dose of medicine and cannot be reused. Read the “instructions for use” at the end of the Prescribing Information and Medication Guide for detailed information about the right way to use KLOXXADO® Nasal Spray.
Storage and Handling
Store KLOXXADO® at room temperature between 68°F to 77°F (20°C to 25°C). Do not expose to temperatures below 41°F (5°C) or above 104°F (40°C). Do not freeze KLOXXADO®. Keep KLOXXADO® in its box until ready to use. Protect from light. Replace KLOXXADO® before the expiration date on the box. Keep KLOXXADO® and all medicines out of the reach of children.
For more information, please see the full Prescribing Information and Medication Guide.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch or call 1-800-FDA-1088.
Distributed by: Hikma Specialty USA Inc., Columbus, OH 43228.
This website is intended for U.S. audiences
Customer Service: Phone 1-800-631-2174 | Email
© Hikma Specialty USA Inc. All rights reserved.
NARCAN® is a registered trademark of Emergent Operations Ireland Limited.
KLOXXADO®️ is a registered trademark of Hikma Pharmaceuticals USA Inc.
The brand statement “Better Health. Within Reach. Every Day.” is a registered trademark of Hikma Pharmaceuticals PLC.
HK-1266-v3
June 2023